Ka noiʻi ʻano kristal lāʻau a me ka loiloi kūlike

Hāʻawi ka mākaʻikaʻi pūnaewele i nā hopena wikiwiki no ka hoʻāʻo ʻana i ka kristal, ʻo ka ʻikepili mau e hoʻolalelale i nā mīkini pane a me nā hopena, e hāʻawi ana i ka optimization, kuhikuhi.

Hiki i nā ʻano kristal like ʻole o ka lāʻau like ke hōʻike i nā ʻokoʻa koʻikoʻi i ka helehelena, solubility, melting point, dissolution rate, bioavailability, etc., no laila e hoʻopilikia ai i ka kūpaʻa, bioavailability, a me ka pono o ka lāʻau.No laila, pono e hōʻoia i ka hele ʻana o ke ʻano kristal i ka wā o ka synthesis lāʻau a me nā kaʻina hana.

I ke kaʻina hana o ka hoʻomohala ʻana i kahi lāʻau lapaʻau hou, pono ia e nānā i ka manawa maoli i ka hoʻokumu ʻana o ka crystalline phase o ka lāʻau lapaʻau i ka hopena hopena synthesis.Hana ʻia kēia i mea e ʻoi aku ka maikaʻi o ke kaʻina hana a hōʻoia i ka hoʻohui ʻia ʻana o ka māhele crystalline target o ka lāʻau.Hiki ke hoʻohana ʻia ka spectroscopy Raman no ka nānā ʻana i loko, e hāʻawi ana i ka nānā ʻana i ka manawa maoli o ka haku mele crystalline i loko o ka hopena synthesis o ka lāʻau, kūpono loa no ka nānā ʻana i nā ʻōnaehana polymorphic a me ka amorphous API.

Hoʻopili ʻo Raman spectroscopy i ka nānā ʻana i ke aniani aniani no nā ʻano hopena like ʻole, e like me ka hōʻike ʻana e kahi hui lāʻau lapaʻau i ka hoʻāʻo ʻana i nā pūʻulu hana.Ua hōʻoia ka hopena i ka alignment me ka lāʻau lapaʻau ikaika, e hōʻike ana i ka noiʻi kūleʻa.ʻO nā palena ma mua o ka hoʻohana ʻana i ka XRD a me nā mea hana lab ʻē aʻe i alakaʻi i nā kaohi ʻikepili a me nā pōʻai hoʻomohala hoʻonui.ʻO kekahi hihia i hōʻike i ka hoʻokaʻawale ʻana i ka manawa maoli o ka hoʻololi ʻana i ke aniani kristal i nā kaʻina hana ʻeono, e hāʻawi ana i nā ʻike koke i nā hopena huahana.